Augmentin is a combined antibiotic containing amoxicillin and clavulanic acid, with a broad spectrum of bactericidal action, resistant to beta-lactamase.
Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many Gram-positive and Gram-negative microorganisms. Amoxicillin is destroyed by beta-lactamase, and does not affect microorganisms that produce the enzyme. The mechanism of its action consists in inhibiting the biosynthesis-mucopeptides of the cell wall.
Clavulanic acid is a beta-lactamate structurally related to penicillins, which has the ability to inactivate a wide range of beta-lactamases. Beta-lactamases are produced by many Gram-positive play negative bacteria. The action of beta-lactamases can lead to the destruction of some antibacterial drugs even before their effects on pathogens. Clavulanic acid blocks the action of enzymes, restoring the sensitivity of bacteria to amoxicillin. In particular, it has a high activity for plasmid beta-lactamases, which are often associated with drug resistance, but less effective against type 1 chromosomal beta- lactamases.
The presence of clavulanic acid in the composition of Augmentin protects amoxicillin from the destructive action of beta-lactamases and expands its spectrum of antibacterial activity with the inclusion of microorganisms usually resistant to other penicillins and cephalosporins.
– hypersensitivity to beta-lactams, for example, kpenicillinam and cephalosporins
– jaundice or liver dysfunction, developed on a background of application of Augmentin or beta-lactam antibiotics
– Infectious mononucleosis
Interaction with other drugs
It is not recommended to use Augmentin simultaneously with probenicid. Probenicid reduces tubular secretion of amoxicillin, and therefore, the simultaneous use of Augmentin and probenicida can lead to an increase in blood levels of amoxicillin.
The simultaneous use of allopurinol and Augmentin may increase the risk of allergic reactions. Data on the simultaneous application of allopurinol and Augmentin are currently not available.
Augmentin affects the intestinal flora and leads to a decrease in the reverse absorption, a decrease in the effectiveness of combined oral contraceptives.