Azithromycin is an antibiotic from the group of macrolides-azalides, which has a bacteriostatic effect and a wide spectrum of action against gram-positive and gram-negative bacteria.
The administration of Azithromycin is prescribed in the case of confirmed bacterial forms of infection. The drug belongs to the group of macrolide and azalide antibacterial agents. The active substance is of a chemical nature and a complex multilevel formula. The medicine belongs to the third generation of bactericidal preparations with minimal resistance to it of various pathogenic bacteria. This allows the drug to be used in various forms of inflammatory diseases. The main form for use is gelatin capsules, inside of which is a crystalline powder of white color. Take capsules should be whole, without pre-opening. This is due to the fact that the hydrochloric acid of gastric juice can negatively affect the components of the drug. Capsular form allows you to convey it unchanged to the cavity of the small intestine, where there is no aggressive acidic medium.
The main effect of azithromycin is directed against a wide range of bacterial forms of infections. When ingested, the active substance comes into contact with the inclusion of ribosomes of cells. Due to the formation of persistent bonds, the production of protein compounds inside the bacterial cell is blocked. Thus, with therapeutic dosages, a bacteriostatic process is achieved with the slowing down and suppression of fission and multiplication of bacterial microflora. To rapidly destroy the microbial flora, an increase in the concentration of the active substance in the blood plasma is required.
The number of bacteria that are sensitive to this drug include:
- All kinds of streptococci;
- Bordetella and Campylobacteria;
- Anaerobic microflora;
- Mycoplasma and ureoplasm.
In some cases, azithromycin instructions for use can be used for tissue damage with spirochaetes.
After ingestion, the active substance penetrates into the blood for 30 minutes. After one hour, the plasma concentration reaches 38 percent. The maximum bioavailability occurs after 2 hours after taking a therapeutic dose of 500 mg. For a full-fledged treatment, you need to take an antibiotic azithromycin for at least 3 consecutive days. In severe forms of infection, longer courses of treatment are needed.
Indications for the use of azithromycin:
- Acute infections of the upper respiratory tract, including tonsillitis, catarrhal sore throats,
- pharyngitis, tracheitis;
- Acute and chronic infections of the lower respiratory tract – bronchitis, bronchiolitis,
- bronchiectatic disease, pleurisy, pneumonia;
- Otitis media in the acute stage;
- Frontitis, etmoiditis, maxillary sinusitis;
- Acute urethritis and cystitis;
- Pyelonephritis caused by sensitive microflora;
- Inflammatory processes in soft tissues – erysipelas, dermatoses and dermatitis with a purulent
- detachable substrate;
- Cholecystitis, duodenitis, peptic ulcer of the stomach and duodenum.
In dentistry, azithromycin 500 mg is used for acute forms of adnexitis and bacterial vaginitis. This drug is likely to help prevent the risk of adhesions and obstruction of the fallopian tubes.
The drug azithromycin 250 mg is effective in diseases of the oral cavity. In particular, its use is widely practiced with fluxes, periostitis and periodontitis. After tooth extraction and suppuration, the wells can also be prescribed for taking this medication.
It does not have sufficient efficacy for diseases of the spider webs of the brain and does not have a pathogenic effect on the meningococcal forms of infection. Therefore, with meningitis, encephalitis and arachnoiditis is not used as a first-choice drug. But it can be used as an auxiliary preparation in complex antibacterial therapy.