Finasteride is a synthetic drug that is intended for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness. The drug is a type II 5α-reductase inhibitor. 5alfa-reductase is an enzyme responsible for converting testosterone to dihydrotestosterone (DHT). This is a synthetic 4-azasteroid compound. Well reduces the level of DHT in the blood and in the gland tissue.
Properties of finasteride
Most sports organizations have banned the adoption of Finasteride, due to the fact that it began to take in order to hide the use of steroids. Since 2005, Finasteride was included in the list of substances banned by the World Anti-Doping Agency. Despite this, in 2009 the drug was excluded from this list. Among the famous athletes who took Finasteride to prevent hair loss, and then were excluded from international competitions, were skeletonist Zak Lund, bobsledder Sebastian Gattuso, footballer Romario and goalkeeper in ice hockey Jose Theodore.
In medicine, finasteride is used to treat benign prostatic hyperplasia (BPH), popularly known as “prostate enlargement”. The dose recommended by the FDA is 5 mg once a day. In order to achieve therapeutic results, it may take six months to take Finasteride, or even more. If you stop taking the drug, the disease can return in about 6-8 months. Finasteride (Propecia) affects the decrease in the manifestation of symptoms that are associated with prostate adenoma (eg, difficulty urinating, night trips to the toilet, delay in the beginning of urination and weakening of the flow of urine).
For 5 years, we examined men who had a mild to moderate degree of alopecia. When summarizing, it was found that two of the three men who took 1 mg of Finasteride daily, resumed hair growth. And, conversely, all men who did not take Finasteride, hair loss was observed. In the same study, based on photographs taken by an independent group of dermatologists, it was determined that 48% of patients who took Finasteride had visible hair regrowth, and 42% had no further hair loss. The average amount of hair in the treatment group remained above the original mark. Differences in the amount of hair between members of the Finasteride groups and placebo, throughout the study, has steadily increased. Finasteride is effective only when it is taken. Hair that has grown during admission, have the property of falling out for 6-12 months after discontinuation of therapy. In clinical studies it became known that Finasteride and Minoxidil affect both the parietal region and the hair growth line, but more effectively – precisely on the parietal region. Recently completed a 10-year study of 118 men who suffered androgenic alopecia (baldness). Participants took Finasteride at a dose of 1 mg / day, it became known that 86% of men who decided to continue treatment for all 10 years, noted an increase or retention of hair growth rates, and only 14% of patients continued and further loss of hair . It was found that patients who experienced the greatest hair growth during the first 12 months, noted more pronounced hair growth after 5 years of treatment.
Side effects of finasteride
Among the side effects of Finasteride are the following: impotence (1.1-18.5%), excessive ejaculation (7.2%), decreased ejaculate volume (0.9-2.8%), impaired sexual function (2.5% ), Gynecomastia (2.2%), erectile dysfunction (1.3%), impaired ejaculation (1.2%) and pain in the testicles. The termination of manifestations of side effects was observed both in men who interrupted treatment, and in most men who continued. The manufacturer also reports cases of persistent erectile dysfunction, despite the discontinuation of the drug. In December 2010, Merck added depression to the list of side effects of the drug. In November 1997, the FDA refused to approve the drug Propecia for the treatment of male pattern baldness. Without questioning its effectiveness, members of the Committee expressed concerns about the likelihood of a long-term adverse effect on sexual function and, quite likely, even on the ability to reproduce. This is due to data on the reduction in ejaculate levels.