Premarin 0.625mg (28 pills)
0.625mg (28 pills) of Premarin Pfizer
Premarin is an estrogen preparation that regulates the work of the female reproductive system.
The main active substance of the drug is estrogen, which forms secondary sexual characteristics in women. Getting into the blood, it stimulates the synthesis of proteins and DNA. In this case, the sensitivity of the uterus increases, the total cholesterol level decreases, HDL is increased, normal bone structure remains. Due to this, such symptoms of menopause as heart palpitations, pressure surges, increased sweating, a sharp change in mood, hot flashes to the upper trunk, nervousness, irritability, tearfulness, unmotivated panic, increased appetite and weight gain are reduced.
The drug is indicated as a hormone replacement therapy before, during and after menopause, with ovarian hypofunction, sexual infantilism, breast carcinoma, postmenopausal
Premarin – Clinical Pharmacology
A significant degree of responsibility for the development and maintenance of the female reproductive system and the secondary sexual characteristics of endogenous estrogens. Although in the dynamic equilibrium of metabolic interconversions there are circulating estrogens, estradiol, the main intracellular human estrogen and significantly more potent than its metabolites, estrone and estriol, at the receptor level.
The main source of estrogens in a normally adult female cycling is the ovarian follicle, which releases 70 to 500 μg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, the most endogenous estrogens are obtained by converting Androstenedione, secreted by the adrenal cortex, to estrone in peripheral tissues. Thus, estrone and sulfate conjugated form, estrone sulfate, are the most common circulating estrogens in postmenopausal women.
Estrogens act through binding to the nuclear receptors in the estrogen of a flexible tissue. To date, two estrogen receptors have been identified. They differ in the proportion of fabric tissue.
Circulating estrogens modulate the secretion of the pituitary gland gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through the mechanism of negative feedback. Estrogens take measures to reduce elevated levels of these gonadotropins in postmenopausal women.
Before applying Premarin, one should consult with the doctor in order to choose the optimal dosage of the drug. Usually during cyclic use take 625 mcg, at 1.25 mg per day. Take the drug for three weeks, then there is a one-week break.