Vermodje Exemever during the period of the steroid cycle prevents side effects that can cause flavoring steroids. It is worth noting that the action of Vermodje Exemever is fundamentally different from the action of the usual for many athletes Tamoxifen.
As is known, Tamoxifen does not exert any influence on the process of aromatization. It simply begins to interact with cellular estrogen receptors, not allowing estrogen to join them and form a bond. Vermodje Exemever acts on the process of aromatization and suppresses it. The structure of Vermodje Exemever is very similar to the steroid of natural origin androstenedione. The principle of action of Exemever is that it irreversibly binds the active enzymes to hormones. As a result, hormones lose their activity. Exemever does not have non-estrogenic, non-progestogenic activity. But it is characterized by mild androgenic activity.
The steroid representative of the third generation of aromatase inhibitors is exemestane, which, by covalently interacting with aromatase during the first oxidation cycle, leads to an efficient selective irreversible inactivation of the enzyme and reduces the synthesis of estrogen in the body by 97%.
Like anastrazole and letrozole, it is well tolerated by patients. Produced for oral administration in the form of tablets of 25 mg, which is the daily dose in the treatment of disseminated breast cancer in postmenopausal women.
Exemestane, which is approved and used in oncology in the United States as a drug of the first line of endocrine therapy for breast cancer and after taking drugs of the IMED class, has not been sufficiently studied in clinical conditions. However, it has been found that with respect to the aromatization process and the degree of estrogen accumulation, it has an activity higher than tamoxifen but less than anastrozole (comparative study of AS KO, 2002).
Vermodje Exemever Dosage
Exemestane is a new generation drug that blocks enzymes responsible for aromatization. Exemestane is called the real killer of aromatase. The principle of action of this drug is that it blocks the enzymes responsible for the synthesis of estrogens.
The amount of necessary Exemestane is calculated taking into account the used anabolic steroids, individual sensitivity to aromatase inhibitors. In the most general case, the dosage of exemestane is 12.5 mg per day. It should be remembered that the use of exemestane serves only to control the desired level of estrogen. Complete reduction or removal of estrogens adversely affects the body.
The duration of taking the drug is 2-4 weeks. In the event that the athlete does not start taking aromatase inhibitors on time and already noticeable or even pronounced estrogenic side effects, you should begin taking 25 mg of Exemestan daily and do not stop taking the drug until the signs of gynecomastia disappear completely.
It is recommended to take Exemestan during meals or immediately after it. In this case, the bioavailability of the drug will increase by 40%, and within two hours its maximum concentration in the blood will be reached.
Take the drug can and athletes who suffer from liver or kidney disease. However, in this case, the systemic effect of the drug is increased by 2-3 times. Such athletes are recommended to reduce the dosage of Exemestan.