Mechano Growth Factor
Mechano growth factor (MGF) is a structural modification of insulin-like growth factor (IGF-1), a variation in the form of IGF-IEs. Mechano growth factorproduction is observed as a result of physical exertion or muscle tissue trauma, because MGF is a reducing substance for muscles.
IGF-1 has a number of unique isomers (proteins having similarities in the structural and functional plans). Mechano growth factor serves as a local variation of the IGF-1 compound, and is produced by the muscles as a response to their trauma or overload. MFR is quite sensitive to any mechanical signals, especially to the overload of the muscular system. Strictly speaking, therefore, the MFR is called a mechanical growth factor.
MFR is synthesized during muscle loads in the muscles themselves and performs the function of regenerating muscle tissue. MGF is one of the main factors whose task is to control the recovery and the rate of muscle growth. MGF produces a synthesis of myoblasts (germ cell muscle cells), which accelerates the growth and regeneration of muscles after training. The physiological role of mechano growth factor was well studied on the model of Buy Clenbuterol the cell in vitro and in the experiment with mice. Mechanical growth factor, in contrast to IGF-1, stimulates, for the most part, the processes of dividing the sleeping cells of muscle tissue (myoblasts), by activating a variety of receptors. Lowering the level of MGF production is the main reason, because of which muscle contractions are observed in patients with dystrophy and elderly people.
The whole chain of biomechanical influence of GR can be divided into 3 links:
- The first – Synthesis of GH in the pituitary gland (the main effect of growth hormone is the destruction of excess fat)
- The second – Change of growth hormone to the form of IGF-1 directly in the liver (the main effect of IGF-1 is the regeneration of tissues and organs, etc.)
- The third – Synthesis of MFR in muscle tissues (muscles grow and recover, adapt to stresses).
It follows that mechano growth factor is the final link. In addition, by the level of stimulation of muscle growth, IHF is one of the main intermediaries between GR and IGF-1.
The use of MGF as a drug was limited in the beginning, because this substance disintegrated after an injection within a couple of minutes. MGF production in the body is continuous, so the concentration is kept at a high level for a long time. The injections every half an hour are difficult to do. Then scientists found a simple and simultaneously brilliant solution – pegylation. As a result, the mechano growth factor molecule was combined with a polyethylene glycol molecule, which serves as a protection against its destruction, and at the same time does not reduce the biological activity and efficiency. Hence the conclusion – almost all modern preparations are Peg-MGF pegylated, and pure MFR is useless to use.
In the process of pegylation, a protein with an artificial protective binding is formed, which protects the main protein from enzymes and inhibitors, which makes the protein molecule much more stable and durable. Molecules after pegelation are absolutely safe and give the same effect on the body as their predecessors. The protective binding of PEG is inert and does not bind to other substances in the body, and has no effect on the quality of the metabolism (non-toxic) and is quickly excreted in the urine. PEG is approved for use in dosage forms in Russia, the USA and some other developed countries, in addition it is approved as a food supplement. PEG is widely distributed as a filler and as a binding agent for food and cosmetics.
With PEGelirovaniya PEG MGF (PEG IFG) becomes the medication over prolonged exposure, and becomes more accessible to a wide number of persons. PEG MFR can be taken only 3 to 4 times a week to achieve the required results. The only negative factor for long-term use PEG MGF is the emergence of addiction, but it’s not scary – just from time to time to take a break in the use of the drug.
It is believed that the pegylated peptides will soon be able to be determined during the anti-doping controls, and their detection time will be very significant. For example, PEGylated erythropoietin variant – Mirsera – is determined by more than one month, in contrast to most of EPO, which refers to read one of these days. MGF is quickly destroyed in the digestive tract, and therefore is taken solely by injections subcutaneously or intramuscularly.
MGF: Mechano Growth Factor
Mechano Growth Factor Course
MFR for today continues the passage of clinical trials, but this fact does not stop athletes. In the west, it is already widely used to accelerate muscle growth. The experience with taking this drug was formed by trial and error. The result was the following reception scheme:
On average, the dosage of Peg-MGF is 1000-4000 μg per week. A significant dosage will not result in a significant improvement in the results.
On days when training is underway, the injection of the drug is performed immediately after the end of training to maximize imitation of physiological secretion, preferably locally by intramuscular injection, because natural mechano growth factor is produced just as a result of damage and loads on muscle tissue.
In days of rest, both local and general (subcutaneous) injections are allowed.
It is sometimes possible to use MGF in mega doses up to 1000 μg with a regularity of 4-7 times a week, before training. However, reviews of athletes indicate a slight increase in the result, because taking such dosages is considered inexpedient.
Tests in rats have shown that the cross-sectional area of muscles increases by 25% in 3 weeks from just one injection of MFR. When testing such a scheme with an insulin-like growth factor, the growth of the cross-sectional area of muscles was only 15%.
In addition, in the course of research, it became apparent that MFR is most effective at a young age. The older the person, the lower the response of the muscles to the receipt of the drug.
Based on the summary data on the use of MFR, results were obtained that a 5-week course of the drug contributes to:
- Accelerated muscle growth due to the growth rate of cell division (hyperplasia), cell growth in the volume (hypertrophy) and prolongation of their life, at any age
- Reducing the fat content by about 5-6%
- Increased Stamina
- Musculature development
- Appearance of pronounced venous traction
- The growth of new vessels in the muscular and bone tissues (proved by Deng M, Wang Y. in 2012)
- Growth of immunity
- Improvement of the appearance and properties of the skin
- Decreased cholesterol in the body
- Strong bones
- Fast tissue repair process
- Protection of the nervous system (neuroprotective effect)
To date, preparations of this kind are still undergoing a series of clinical trials, and therefore, there is as yet no comprehensive information on the presence of pronounced side effects. MFR affects cell DNA, which theoretically can have negative consequences in the future.
Side effects of mechanical growth factor (according to research):
- Hypertrophy of the myocardium (heart) – is justified experimentally by van Dijk-Ottens M in 2009. In this case, there was a simultaneous demonstration of the dual action of the drug on the heart: protective – without loads and damaging – with loads.
- A study by Armakolas A, Philippou A. in 2010 demonstrated the involvement of MFR in the biology of prostate cancer in men.